Q1. A 52-year-old man presented with haemoptysis, weight loss, worsening breathlessness and retro-sternal chest pain. He was a lifelong heavy smoker. His ECOG Performance Status was '1'. His chest X-ray was abnormal. A CT scan of chest and abdomen demonstrated a large mass in the right lower lobe invading into the mediastinum and pericardium, extensive mediastinal lymphadenopathy, and bone metastasis (T4, N3, Mlb). Bronchoscopy and biopsy confirmed a squamous cell carcinoma. Mutation analysis revealed that EGFR and K-ras genes were both wild type. What is the most appropriate first-line therapy?
- (1) docetaxel
- (2) gefitinib
- (3) pemetrexed and cisplatin
- (4) gemcitabine and cisplatin